Intranasal pitavastatin attenuates seizures in different experimental models of epilepsy in mice

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Muhammad Usama Ashhar, Mohd. Zubair Ahmad, Vikas Jain, Nidhi B. Agarwal, Farhan J. Ahmad, Gaurav K. Jain
This study was carried out to evaluate the effect of intranasal pitavastatin (PVS) on pentylenetetrazole (PTZ)-induced seizures, increasing current electroshock (ICES) seizures, and status epilepticus in mice. Intranasal PVS, 0.5 and 1.0mg/kg, ...

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Protective effect of naringin on pentylenetetrazole (PTZ)-induced kindling; possible mechanisms of antikindling, memory improvement, and neuroprotection

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Phani Kumar Kola, Annapurna Akula, Lakshmi Sudeepthi NissankaraRao, R. CH. Sekhara Reddy Danduga
The present study investigated the effects of Naringin on seizure severity, progress of kindling, memory impairment, oxidative stress, neurochemicals, and neural damage in Pentylenetetrazole (PTZ)-induced kindling. Alternate intra-peritoneal injections of PTZ induced kindling at 22 injections of PTZ. In comparison with ...

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The role of necroptosis in status epilepticus-induced brain injury in juvenile rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Qianyun Cai, Jing Gan, Rong Luo, Yi Qu, Shiping Li, Chaomin Wan, Dezhi Mu

Purpose
To study the role of necroptosis in status epilepticus (SE)-induced injury in the developing brain and the possible associations of necroptosis with epileptogenesis and cognitive dysfunction.
Methods
The lithium-pilocarpine epilepsy model was ...

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Epilepsy may cause increased pain sensitivity: Evidence from absence epileptic WAG/Rij rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Sibel K. Velioglu, Oznur Gedikli, Mehmet Yıldırım, Ahmet Ayar

Objective
The comorbidity of epilepsy and pain disorders as well as effectiveness of certain therapeutic approaches in both conditions attracted attention to epilepsy–pain interactions. This lead to the discovery of significantly shared pathophysiological mechanisms although many aspects remain largely unknown. To test the hypothesis that epilepsy ...

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The possibility of adverse effect of Kv7-channel opener retigabine on memory processes in rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Ewa Zwierzyńska, Agata Krupa-Burtnik, Bogusława Pietrzak

Objective
Retigabine is a novel antiepileptic drug with a unique and complex mechanism of action which allows its use in many diseases associated with impaired neuronal activity. This study sought to examine the impact of retigabine on two types of memory in rats.
Methods
Adult male Wistar rats were ...

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Perampanel with concomitant levetiracetam and topiramate: Post hoc analysis of adverse events related to hostility and aggression

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Steve Chung, Betsy Williams, Cindy Dobrinsky, Anna Patten, Haichen Yang, Antonio Laurenza
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1–3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy ...

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The psychological costs of comparisons: Parents’ social comparison moderates the links between family management of epilepsy and children’s outcomes

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Teresa P. Mendes, Carla A. Crespo, Joan K. Austin
Parents play a key role in how children deal with epilepsy. When diagnosed with health conditions, people seek comparison information from fellow patients and families, and this information has consequences for how they evaluate their situation. This study examined the moderating role of parents’ social comparison orientation ...

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Unraveling complex relationships among dysphoric disorder, localization-related epilepsy, and mood disorders

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Tetsufumi Suda, Yasutaka Tatsuzawa, Taichi Mogi, Aihide Yoshino

Background
Dysphoric disorder (DD), characterized by intermittent pleomorphic symptoms, has been believed to be specific to epilepsy. However, our previous study revealed that DD in patients with localization-related epilepsy was associated with a lifetime diagnosis of mood disorders. The present study was conducted to estimate the prevalence ...

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Provision of sudden unexpected death in epilepsy (SUDEP) information among Malaysian parents of children with epilepsy

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Choong Yi Fong, Wei Kang Lim, Ann Nie Kong, Pei Lin Lua, Lai Choo Ong
Sudden unexpected death in epilepsy (SUDEP) is an important cause of mortality in epilepsy. To date, there is only one published UK study evaluating information provision of SUDEP among parents of children with epilepsy (CWE), and there ...

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Clinical utility of serum lactate levels for differential diagnosis of generalized tonic–clonic seizures from psychogenic nonepileptic seizures and syncope

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Ebru Apaydın Doğan, Ali Ünal, Aslıhan Ünal, Çağla Erdoğan

Background
The differential diagnosis of generalized tonic–clonic seizures (GTCS), psychogenic nonepileptic seizures (PNES), and syncope constitutes a major challenge. Misdiagnosis rates up to 20 to 30% are reported in the literature.
Purpose
To assess the clinical utility of serum lactate levels for differentiation of ...

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