Posttraumatic epilepsy (PTE) is defined as recurrent and unprovoked seizures occurring >1 week after traumatic brain injury (TBI). Animal studies of PTE are lengthy and expensive. In this study, we developed a cost‐effective PTE animal model using zebrafish to bridge the gap between in vitro studies and low‐throughput animal studies.
We used two different sets of parameters (G1 and G2) to induce closed‐head TBI in adult zebrafish using pulsed high‐intensity focused ultrasound. Injured fish and naive controls were evaluated for behavioral deficits ...Seguir leyendo →