Brivaracetam in absence status epilepticus

Brivaracetam (BRV) is a high-affinity synaptic vesicle glycoprotein 2A ligand with fast brain penetration, rapid onset of action and intravenous (IV) formulation, suggesting a potentially use in emergency setting [1]. The role of BRV in patients with genetic generalized epilepsy (GGE) presenting with absence status epilepticus (ASE) is currently limited [1,2], and further experiences are required to warrant recommendation in this emergency situation.

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The Association Between HLA-A*03:01 and HLA-B*07:02 Alleles and Oxcarbazepine-induced Maculopapular Eruption in the Uighur Chinese Population

Epilepsy is one of the most common neurological conditions, with more than 2% of the worldwide population affected, according to the latest study [1]. Patients with epilepsy need long-term or lifelong aromatic antiepileptic drugs (AEDs) [2]. Maculopapular eruption (MPE) is the most common clinical manifestation of cutaneous adverse drug reactions (cADRs) in patients taking aromatic AEDs [3]. MPE is characterized by small pink patches and papules on the skin. Clinically, the overall incidence of various forms of AED-induced cADRs is ...

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Phenytoin versus fosphenytoin for second-line treatment of status epilepticus: propensity score matching analysis using a nationwide inpatient database

Status epilepticus (SE) is an emergency condition in which a rapid seizure cessation and circulation/respiration maintenance are crucially important for avoiding death and irreversible cerebral damage [1,2]. Benzodiazepines have been established as first-line treatment for SE [3,4]. Second-line treatments of longer-acting antiepileptic drugs (AEDs) are administered later to stop SE definitely and prevent recurrence [5].

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Anticonvulsant Effects of Sertraline: A Case Report

In people with epilepsy, depressive disorders are frequent comorbidities, constituting a challenge to complex treatment strategies. Administering antidepressants to such individuals is controversial because multiple studies and case reports indicate pro-convulsant effects for tricyclic antidepressants (TCAs) and in some cases for serotonin selective reuptake inhibitors (SSRIs) as well.[1] For this reason, TCAs are contraindicated in depressed people with epilepsy while SSRIs are often used in this population even though their possible pro-convulsant effects are variable.[2] We report the case of ...

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Psychiatric Co-Morbidities and Factors Associated with Psychogenic Non-epileptic Seizures: A Case-control study

Psychogenic nonepileptic seizures (PNES) are paroxysmal subjective or objective clinical manifestations resembling seizures that do not arise from epileptiform cortical discharges. These are now considered to be ‘experiential and behavioural responses’ to internal or external stimuli [1,2]. An international consensus clinical practice statement issued in 2011 ranked PNES among the top three neuropsychiatric problems, along with anxiety/ depression and psychosis [3]. It is now considered to be a biopsychosocial disorder with multifactorial aetiology [4,5].

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Predictors of successful Ramadan fasting in Muslim patients with epilepsy: A prospective study

Ramadan is the name of a month in the Muslim lunar calendar. Ramadan fasting is a basic principle of Islam that involves fasting from dawn to sunset for one lunar month. During Ramadan, healthy adult Muslims are allowed to eat and drink only between sunset and dawn. Fasting is not obligatory for prepubertal children, menstruating women and individuals with mental illness.

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Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus

Status epilepticus (SE) is one of the most common life-threatening neurological emergencies in children. The estimated incidence of convulsive SE in children is 10-38/100 000 every year, and mortality is currently between 0% and 7.5% [1–4]. The paediatric Status Epilepticus Research Group (pSERG) in the United States has reported an association between treatment delays and unfavourable short-term outcomes in children with refractory SE [2,4]. Age at onset and duration of SE were independently associated with worse neurocognitive outcomes in a ...

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Association of common genetic variants with vitamin D status in Malaysian children with epilepsy

Epilepsy is the most common paediatric neurological disorder, with an average annual rate of 5–7 new cases per 10,000 children [1]. Treatment of epilepsy involves long-term therapy of antiseizure medication, which expose patients to potentially undesirable metabolic bone health adverse effects such as vitamin D deficiency [2]. Vitamin D is an important determinant of growth and body development during childhood and adolescence [3–5]. Paediatric studies have shown that long-term antiseizure medication therapy is associated with vitamin D deficiency resulting in ...

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Trends in hospitalization and readmission for pediatric epilepsy and underutilization of epilepsy surgery in the United States

Epilepsy is one of the most common neurologic disorders, affecting 0.5%–1.0% of the general population [1,2]. Approximately 35% of patients with epilepsy have medically refractory epilepsy and epilepsy surgery may be the only curative option [3,4]. Despite adequate trials of antiepileptic drugs, the persistence of seizures in refractory cases accounts for more than 75% of the cost of epilepsy care in the United States [5,6]. Although epilepsy surgery for well-selected candidates with medically refractory epilepsy could achieve seizure freedom in ...

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