Does glucose influence multidien cycles of interictal and/or ictal activities?

Studies of epilepsy surveillance systems, ictal and interictal epileptiform activities (IEA) show circadian and multidien patterns, with multiday patterns of rising phase IEA suggesting seizures are more likely [1–4]. IEA are non-ictal patterns that Responsive Neurostimulation Systems (RNS) may detect via surveillance EEG, patterns could include spikes, repeated sharp waves, polyspikes and fast oscillations [3,5]. Biomarker studies might clarify how RNS evident mulitidien IEA and ictal risk are related [4,6,7].

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The perceived impact of COVID-19 and associated restrictions on young people with epilepsy in the UK: young people and caregiver survey

The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is having a profound effect on all societies. It has resulted in tens of millions of infections and over 1 million deaths worldwide (https://covid19.who.int/ accessed 19th October 2020). Countries have taken unprecedented steps to respond to the public health threat posed by the pandemic. In the UK the government imposed a range of restrictions in late March 2020 including a directive to stay at ...

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Impact of COVID-19 pandemic on epilepsy practice in India: A tripartite survey

The ongoing global Coronavirus Disease (COVID-19) pandemic, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected the health care including neurologic care world over. [1,2] In addition to the direct affection of nervous system by the SARS-CoV-2, the COVID-19 pandemic may have indirect impact on patients with non-COVID-19 diseases [3]. This indirect impact mainly results from the reluctance of the patients with non-COVID diseases to seek medical care because of the fear of contacting COVID-19 infection ...

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Personality changes in patients with refractory epilepsy after surgical treatment: a systematic review

Epilepsy is one of the most serious and common neurological diseases, affecting approximately 50 million people worldwide [1]. Epilepsy is known to be a potentially disabling, chronic, and socially isolating condition, especially in refractory cases. As a severe disease of the central nervous system, it can influence cognitive functions, affecting attention and memory [2,3]. But does epilepsy have an impact on patients’ personality? Personality is defined as the characteristic sets of behavior, cognition, and emotional patterns that develop from biological ...

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Sleep in Dravet syndrome: A parent-driven survey

Dravet syndrome was first described in 1978 as a rare form of epilepsy that generally presents in the first year of life [1]. While Dravet syndrome is often characterized as a seizure disorder, it is a multi-faceted early life developmental and epileptic encephalopathy (DEE) that impacts many areas of functioning. There are few systematic investigations that characterize these other features of Dravet syndrome.

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A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU setting

Super-refractory status epilepticus (SRSE) is defined as status epilepticus which continues for 24 hours or more after the initiation of anaesthesia (Shorvon and Ferlisi, 2012) and includes those cases which recur upon reduction or withdrawal of anaesthetic agents. Evidence suggests that approximately 15% of all cases of status epilepticus enter super-refractoriness. Despite its high mortality, it remains poorly understood with only a few published studies on treatment and prognosis (Kantanen et al., 2017; Kantanen et al., 2015).

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Topiramate rectal suspensions in pediatric patients

We report our experience with topiramate rectal suspensions in a single center case series of three patients <1 year of age from 2017 to 2020 who received topiramate per rectum after being placed nil per os (NPO) status at a free standing children’s hospital. The objective was to describe the compounding methods and clinical outcomes of three of the youngest patients to receive topiramate rectal suspensions. All three patients received topiramate per rectum for 2–4 days. No adverse effects or increase ...

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THE EPILEPSY SPECIALIST NURSE: A MIXED-METHODS CASE STUDY ON THE ROLE AND ACTIVITIES

The epilepsy specialist nurse (ESN) role was first created and described in the United Kingdom in 1988 (1), and has evolved since then. There is still a lack of clarity about the functions that constitute the role of an ESN (2,3), however, ESNs have a complex and multifaceted role as they operate in a range of settings, collaborate with different professional groups, and assist both patients and carers (4–6). The ESN has been described as “an expert and essential part ...

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