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Publication date: May 2018Source:Epilepsy & Behavior, Volume 82
Author(s): Peipei Wang, Yong Guan, Xiaoyan Lin, Qiang Wang, Chun Fu, Xiaogang Wang, Shaoping Lv
ObjectiveIn recent years, the Status Epilepticus Severity Score (STESS) has been widely used to predict survival conditions of patients with status epilepticus (SE). However, the diagnostic value of STESS has not yet been evaluated. We therefore performed this meta-analysis to assess the overall diagnostic accuracy of STESS for predicting survival condition of patients with SE.MethodsSystemic searches for relevant published studies were conducted in EMBASE, PubMed, Web of Science, and Cochrange databases up to July 2, 2017. Quality Assessment of Diagnostic Accuracy Studies (QUADAS) was used to evaluate the quality of included studies. All statistical analyses were performed using Stata12.0 and Meta-DiSc software.ResultsA total of 11 studies including 12 observations with 1356 patients were included in this meta-analysis. Summary estimates of the diagnostic value of STESS for survival condition of patients with SE were listed as follows: sensitivity, 0.81 (95% confidence intervals (CI): 0.76–0.85); specificity, 0.53 (95% CI: 0.50–0.56); positive likelihood ratio (PLR), 1.86 (95% CI: 1.57–2.21); negative likelihood ratio (NLR), 0.38 (95% CI: 0.30–0.48); diagnostic odds ratio (DOR), 5.24 (95% CI: 3.49–7.87); and area under the curve (AUC), 0.81. Metaregression analysis showed that ethnicity, study design, publish year, and sample size did not significantly influence the diagnostic performance statistically (all P>0.05).ConclusionsThe STESS is a promising candidate for predicting survival condition of patients with SE. However, the potential tool should be validated in well-designed studies with larger sample sizes.