Stopping epilepsy treatment in seizure remission: good or bad or both?

The ideal objective of treating a person with epilepsy is of course to induce remission by usage of antiepileptic drugs (AEDs) and ultimately stop the antiepileptic drugs AEDs without causing seizure recurrence [1]. Nearly 70% of patients with new-onset epilepsy eventually enter prolonged terminal seizure remission during treatment with AEDs [2,3]. The continued use of AEDs in children and adults may be associated with adverse effects in a substantial fraction of the exposed population, including behavioural and cognitive and other ...

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Long-term outcome of medically treated epilepsy

The first attempts, in a modern sense, to explore the medical and social outcome of patients with epilepsy were made in the 1950s[1] and 1960s[2] based on patients from hospitals and other institutions. According to those studies and the previous literature from 1901-1964 discussed by Rodin[2], the five-year terminal remission varied by etiology between 15-30%. Yet, studies based on unselected population cohorts are needed to get unbiased and valid data on this chronic disorder. The data are important for the ...

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Socioeconomic evaluation of vagus stimulation: a controlled national study

Epilepsy is a serious and chronic neurological disorder that affects all ages from childhood to old age [1]. Epilepsy in adults, children and adolescents is strongly associated with significant morbidities, mortality, stigma and reduced quality of life. It is also associated with educational and professional problems and may therefore have a substantial socioeconomic impact [2,3]. Despite decades of research focusing on its medical or surgical treatment, a significant proportion of patients are left with medically intractable epilepsy and continued seizures.

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OUTCOMES IN NEWLY DIAGNOSED EPILEPSY IN ADOLESCENTS AND ADULTS: INSIGHTS ACROSS A GENERATION IN SCOTLAND

The outpatient services at the Epilepsy Unit in the Western Infirmary, Glasgow, Scotland was set up in September 1982. From the outset patient data were collected prospectively. A focused approach to patients with newly diagnosed epilepsy was developed and a series of 4 analyses have been undertaken over the intervening years, with results from the latest still being written up for publication. A total of 16 published papers have described patient outcomes over the years, focusing on response to different ...

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Frequency of a false positive diagnosis of epilepsy: A systematic review of observational studies

Newly diagnosed epilepsy is estimated at 47 per 100,000 person-years [1]. One study on 5,000 people with epilepsy (PWE) from 15 European countries reported that 96% of PWE were prescribed antiepileptic drugs (AEDs), among whom 88% reported at least one side effect (e.g. tiredness, memory problems, difficulty in concentrating or thinking clearly, nervousness and agitation, etc.) and 31% had changed their AEDs at least once in the last year because of side effects[2]. In addition, a diagnosis of epilepsy can ...

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Patient and caregiver view on seizure detection devices: a survey study

The concern for sudden unexpected death in epilepsy (SUDEP) and the need for better seizure control in persons with epilepsy (PWE) have led to the implementation of seizure detection devices (SDD). Timely identification of seizures may lead to decreased SUDEP risk [1] and a reduction in the potential for seizure related injury and status epilepticus. Accurate detection of seizures and creation of alarms should improve monitoring of treatment efficacy, as patient reporting is not completely reliable [2–4].

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Association between epilepsy and systemic autoimmune diseases: A meta-analysis

Systemic autoimmune diseases (SAD) have gained notoriety as being a risk factor for epilepsy. Conversely, recent studies have reported that epilepsy increases the risk of systemic autoimmune diseases [1,2]. Based on the emerging data, one may speculate that there is an underlying biological mechanism, such as pro-inflammatory conditions and antibodies, which links epilepsy and SAD [2,3]. Numerous studies have focused on clarifying this association, as it could help elucidate the different roles of auto-Abs and inflammation in epileptogenesis.

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