Excitatory and inhibitory (E/I) network dysregulation significantly contributes to the pathogenesis of epilepsy. Neuroligins are postsynaptic cell adhesion molecules that play important roles in maintaining E/I synaptic signaling. The NLGN2 gene, located on 17p13.1, encodes a cell adhesion molecule that is expressed only in the postsynaptic membranes of inhibitory synapses, with high expression in the brain. While NLGN2 variants have been linked to schizophrenia, autism, and developmental delay [1], there are no reports of abnormal NLGN2 variants in patients with epilepsy.
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