Cortical and thalamic hyper-perfusion in non-convulsive status epilepticus. Relationship between perfusion CT patterns and Salzburg EEG criteria

Status epilepticus (SE) is a common neurological emergency, with an incidence of 10-41 cases per 100 000 population [1,2] and a mortality rate of around 20% [2]. Nonconvulsive seizures, nonconvulsive status epilepticus (NCSE), and the postictal state, in particular, may masquerade as a stroke and often represent a diagnostic challenge [3] [4]. Failure in recognizing SE can have important negative consequences leading to incorrect treatment, diagnostic delay and potential treatment adverse effects [5].

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Prevalence, Incidence, and Risk Factors of Epilepsy in Arab Countries: A systematic review

The Arab world consists of 22 countries, geographically located over two continents: Asia and Africa. It traverses an estimated total area of 13,132,327 km2, with a total of 423 million inhabitants across all countries. [1] People in the Arab world share a common language, with very similar cultures and traditions. Throughout the past few decades, the world has witnessed a slow yet steady development of the Arab world in different fields and especially in the medical field. This is evident ...

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Care After Presenting with Seizures (CAPS): An analysis of the impact of a seizure referral pathway and nurse support on neurology referral rates for patients admitted with a seizure

Unprovoked seizures account for around 1.5% of emergency medical admissions in the UK, and a similar number attend an Emergency Department (ED) without need of admission [1, 2]. Around 20% of patients with epilepsy attend an ED each year, [3, 4, 5], and these unplanned attendances and admissions cost the health service around £70-£90 million annually [6, 7].

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COMPUTATIONAL MODELS PREDICTS PREMATURE DEATH IN EPILEPSY?

In their article “The use of computational models in the management and prognosis of refractory epilepsy: A critical evaluation” [1] Rigney and colleagues demonstrated that computational modelling is a new tool that can improve the prognosis and management of refractory epilepsy. In addition, it has also been strongly proposed that these models should be explored for their ability to refine surgical outcomes in individuals with refractory epilepsy [1]. Considering the enormous clinical convergence of Rigney’s study [1], we consider it ...

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Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance.

Epilepsy is a brain disorder that affects people of all ages. It is characterized by an “enduring predisposition to generate epileptic seizures that are the transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain” [1, 2]. Around 50 million people worldwide have epilepsy, making it one of the most common neurological diseases. Nearly 80% of people with epilepsy live in low and middle-income countries [3].

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For submission to Seizure: European Journal of Epilepsy Full-length original research article Perilesional white matter integrity in drug-resistant epilepsy related to focal cortical dysplasia

As a common form of malformation of cortical development, focal cortical dysplasia (FCD) is one of the major etiologies of drug-resistant focal epilepsy and a common pathological finding in those who underwent resective epilepsy surgery [1-4]. It has been proven that drug-resistant focal epilepsy is associated with a pronounced reduction in quality of life, education, and employment prospects. Although the incidence of drug-resistance is high in epilepsy caused by FCD, a minority of those epileptic patients are reported to be ...

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‘TO REVEAL OR TO CONCEAL’- Disclosure strategies in parents of children with epilepsy in India

Epilepsy is a common, chronic neurological disorder affecting children at a prevalence of 3-9 per 1000 children [1,2]. Epilepsy is an example of a concealable stigmatized identity, with visibility either on disclosure of the condition, or occurrence of seizures in public, or other indicators of the disease (e.g., drug-taking) [3]. Disclosing a child’s epilepsy to others is an extremely sensitive issue for parents as disclosure can be fraught with discrimination, rejection, restrictions and bullying.

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Antiseizure medication nonadherence and its associated factors among Epileptic patients in Ethiopia, A systematic review and Meta-analysis

Medication non-adherence is the intentional or unintentional behavior of not filling or refilling a prescription, discontinuing a medication before the course of therapy is completed, failing to adhere to agreed recommendations from a healthcare provider, taking more or less of a medication than recommended, and taking a dose at the incorrect time [1, 2]. Numerous studies have found that a large proportion of epilepsy patients in resource-poor countries do not receive adequate treatment, with many individuals, despite diagnosis and treatment ...

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