Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gastaut syndrome: a network meta-analysis

Lennox Gastaut syndrome (LGS) is an age-dependent epileptic encephalopathy characterized by drug-resistant polymorphic seizures with an onset in early childhood, distinctive electroencephalographic findings (generalized slow spike-wave discharges), and cognitive impairment [1,2]. The multiple seizure types associated with LGS include drop seizures (tonic, atonic, or tonic atonic), atypical absences, and other convulsive seizures (clonic, tonic-clonic, etc.). Drop seizures are often very frequent (occurring multiple times/day) and disabling, with a risk of sustaining injuries acutely and poor long-term outcomes in general (many continue to have recurring seizures in adulthood).

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