Seizure

Epilepsy is a neurological disorder characterised by spontaneous and recurrent seizures. Although epilepsy has a wide range of aetiologies, the cause of seizures often remains unidentified [1]. Epilepsy is a leading cause of disability in young people, and the global prevalence among young people aged ≤19 years is estimated to be almost 1% (i.e., approximately 23 million young people worldwide) [2]. In Australia, about 1 in 200 children are living with epilepsy, with an estimated total direct and indirect annual ...

Epilepsy is a chronic neurological disease characterized by recurrent seizures that places a major burden on patients, their caregivers, the healthcare system, and society [1, 2]. Health-related quality of life (HRQL) is a multidimensional concept aiming to quantify physical, social, cognitive, behavioral, and psychological well-being of patients [3]. Researchers and clinicians have implemented a broad use of HRQL measures to evaluate the impact of diagnoses and therapy in children with chronic health conditions such as epilepsy [4].

Epilepsy is a neurological disorder characterised by recurrent epileptic seizures. Up to 67% of children with epilepsy will have seizures controlled by anti-seizure medication or enter spontaneous remission. [1] Early control of seizures is associated with better developmental outcome [2], but many childhood epilepsies have a poor prognosis for seizure control. [3] Up to 35% of children will be refractory to standard anti-seizure medication [4] and continue to experience regular debilitating seizures.

Juvenile myoclonic epilepsy (JME) is one of the most common generalized epilepsy syndromes in adolescence. The disease is characterized by myoclonic seizures occurring mostly after awakening, absence seizures are seen in one-third of cases, and generalized tonic-clonic (GTC) seizures are less common [1,2,3].

: The Arabic word “Assarɛ” (الصرع) continues to be used to stigmatize Moroccan people with epilepsy (PWE), affecting their quality of life and reducing their likelihood of visiting a doctor.

Seizures induced by movement are very rare reflex seizures; they are focal onset seizures without impairment of awareness and with a dystonic or clonic movement, which can involve the arm or limb on the same side.

KCNQ2-epileptic encephalopathy (EE) usually manifests as a neonatal epilepsy syndrome characterized by tonic episodes, focal clonic activity, and autonomic changes [1]. Early EEG recordings typically show a burst-suppression pattern or a multifocal epileptiform activity [1]. Basal ganglia hyperintensities may be found at early brain MRI. A large majority of children with KCNQ2-EE become seizure-free before three years of age, but developmental impairment remains severe in two thirds of the patients.

Seizures occurring predominantly from sleep provide good evidence for epilepsy, and a nocturnal seizure is duly amongst the major diagnostic criteria for the “first epileptic seizure” [1]. On the other hand, the dictum that psychogenic non-epileptic seizures (PNES) do not occur from sleep is widely accepted by clinical epileptologists and neuropsychiatrists with interest in PNES. Although patients with PNES may often report events arising from sleep [2], video-EEG studies have demonstrated that PNES actually occur during “pseudo-sleep”, i.e., when patients ...

Dear Editor, we read the publication on “Should a scientific epilepsy journal feature a picture highlighting the war in Ukraine on its front cover [1]. The Editor stated, “The main reason I believe it is appropriate for Seizure to feature an image of Ukraine on its front cover is that our concern about the suffering in Ukraine is likely to sensitize us to some more complex emotions, such as shame about feeling less concern about the suffering of people in ...

Ketogenic diet (KD), characterized by high-fat, low-carbohydrate, and moderate protein, is a well-established nonpharmacologic treatment for drug-resistant epilepsy, especially in children [1]. The recent Cochrane Database Systematic Review concluded that children with refractory epilepsy who received KD were 3.16 times more likely to be seizure-free and 5.8 times more likely to have a >50% seizure reduction than children who received usual care [2].