Impact of number of anti-seizure medications on long-term health-related quality of life in children with epilepsy: a prospective cohort study

Epilepsy is a chronic neurological disease characterized by recurrent seizures that places a major burden on patients, their caregivers, the healthcare system, and society [1, 2]. Health-related quality of life (HRQL) is a multidimensional concept aiming to quantify physical, social, cognitive, behavioral, and psychological well-being of patients [3]. Researchers and clinicians have implemented a broad use of HRQL measures to evaluate the impact of diagnoses and therapy in children with chronic health conditions such as epilepsy [4].

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