Clinical Implementation of Ketogenic Diet in Children with Drug-Resistant Epilepsy: Advantages, Disadvantages, and Difficulties

Ketogenic diet (KD), characterized by high-fat, low-carbohydrate, and moderate protein, is a well-established nonpharmacologic treatment for drug-resistant epilepsy, especially in children [1]. The recent Cochrane Database Systematic Review concluded that children with refractory epilepsy who received KD were 3.16 times more likely to be seizure-free and 5.8 times more likely to have a >50% seizure reduction than children who received usual care [2].

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