Control of focal impaired awareness seizures with an oral appliance in a patient with sleep apnea

Focal impaired awareness seizure (FIAS) is a clinical phenomenon with a prevalence of 0.8% that manifests as epileptic discharges commonly located in the amygdala-hippocampal complex. It can cause visual delusions and olfactory, auditory, or affective hallucinations [1]. Obstructive sleep apnea (OSA) is common in patients with epilepsy [2]. Despite their limitations, some studies have revealed an important relationship between OSA and refractory epileptic seizures (RES), as well as between OSA improvement and a corresponding RES improvement with adequate continuous positive ...

Seguir leyendo →
0

Incidence and risk factors of post-cranioplasty seizures

We read with great interest the systematic review by Spencer et al. [1] regarding the risk factors for the development of seizures after cranioplasty in patients that sustained traumatic brain injury. The authors have revealed a pooled incidence and risk factors of post-cranioplasty seizures (PCS). We really appreciate the interesting review for their conclusion, it’s very useful to have a better understanding of PCS. However, after reading this article, we would like to highlight 2 important questions that it raises.

Seguir leyendo →
0

Unverricht-Lundborg Disease: Clinical Course and Seizure Management Based on the Experience of Polish Centers

Unverricht―Lundborg disease (ULD) is a type of autosomal recessive progressive myoclonus epilepsy (PME). The molecular basis for ULD involves mutations in the gene encoding cystatin B, a cysteine protease inhibitor. The gene is located on chromosome 21 at q22.3 [1]. This mutation leads to the multiplication of the C4GC4GCG minisatellite sequence repeats. The normal range of repeats is 2―3, with a premutation range of 12―17, and a causative disease range of 30―80 repeats. However, the number of repeats does not ...

Seguir leyendo →
0

Seizures and Epilepsy Following Cranioplasty

We read with great interest the study by Shih et al [1] regarding the risk factors for seizures after cranioplasty. The article is well written and the authors have concluded that delayed cranioplasty procedures and seizures before cranioplasty were significantly associated with early post-cranioplasty seizures. We really appreciate the interesting research for their conclusion would believe it to be useful to make a treatment decision and prevent seizures in advance in cranioplasty patients. However, after reading this article, we would ...

Seguir leyendo →
0

Risk of valproic acid-related alopecia: a systematic review and meta-analysis

Valproic acid (VPA) is the most commonly administered first-generation antiepileptic drug (AED) and is also useful for a variety of other diseases, including bipolar disorder (BD) [1,2], migraine headache (MA) [3–5] and neuropathic pain [6,7]. The side effects of antiepileptic drugs are often the main factors restricting treatment and drug retention for patients with epilepsy [8,9]. The clinical utility of VPA may be hindered by its adverse drug reactions (ADRs), such as tremors, weight gain, hair loss, gastrointestinal disturbances, heartburn, ...

Seguir leyendo →
0

Underutilization of Epilepsy Surgery in ASEAN countries

Approximately 70 million people currently live with epilepsy worldwide [1]. The availability and accessibility of antiepileptic drugs has been an issue for developing countries. In Asia, the treatment gap has ranged from 28% to as high as 98% [2]. For those who received antiepileptic drugs, there were about one-third of patients who still continue to have seizures [3]. Patients with drug-resistant epilepsy are potential candidates for surgery especially those with surgically remediable syndrome, such as mesial temporal sclerosis or focal ...

Seguir leyendo →
0

Computation of antiepileptic drug retention rates in the presence of a competing risk

A thorough study has been carried out by Larsson et al. [1] based on nation-wide registers, which provides valuable information on the long-term retention rates of the most often prescribed antiepileptic drugs (AEDs) in post-stroke epilepsy. Computation of the retention rates was estimated by using the Kaplan-Meier (KM) methodology. The authors excluded a priori patients who died during the first two months after stroke, while patients who died during the study period (>2 months post-stroke) were censored [1].

Seguir leyendo →
0

Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany

Epilepsy is a common, chronic neurological disease with a clinical hallmark of recurrent seizures that places a major burden on patients, their caregivers, and society [1–3]. Moreover, disease-specific restrictions on self-sufficiency, mobility, career choice, family planning, and other social aspects as well as frequent epilepsy-related accidents and injuries have been shown to be associated with a reduced quality of life (QoL) and increased depression scores [4–7]. QoL is a complex and multidimensional construct representing the general “well-being” of individuals by ...

Seguir leyendo →
0
Página 113 de 179 «...90100110111112113114115...»