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Seizures are common in the neonatal period with an incidence of 1-5 per 1000 term infant [1], and 10-15 per 1000 preterm newborn [2]. Symptomatic of a brain insult in more than 80% of cases [2,3], neonatal seizures are notoriously resistant to anti-seizure medications (ASMs), and associated with a risk of death and a slew of detrimental neurological consequences including neurodevelopmental delays, epilepsy, intellectual disability and cerebral palsy [3]. The most common etiologies include hypoxic-ischemic encephalopathy (HIE) in term infants [4], and intraventricular hemorrhage (IVH) in preterm neonates [2].