In the eye of the beholder: Using a multiple-informant approach to examine the mediating effect of cognitive functioning on emotional and behavioral problems in children with an active epilepsy

Epilepsy is a variety of neurological disorders characterized predominantly by seizures and by the neurobiological, cognitive and psychosocial consequences associated with the condition [1]. Children and adolescents with epilepsy (CAWE) are at risk of having a psychiatric disorder up to five times that of healthy controls [2]. Increased rates of anxiety and depression have been reported in both clinic-based and population-based studies [3–5]. Even children with self-limited epilepsies and average intelligence, or children who are seizure-free and off antiseizure medications (ASMs) have been reported to experience high rates of emotional and behavioral problems (EBPs) [6].

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