Parent reported Health Related Quality of Life (HRQoL) and behaviour in young people with epilepsy before and two years after epilepsy surgery

Epilepsy in children is often associated with emotional and behavioural difficulties [1,2] which have a negative impact on the child’s education [3] and family functioning [4], leading to reduced Health Related Quality of Life (HRQoL).Emotional and behavioral difficulties in childhood have a very significant negative impact on a child’s functioning including on the child’s education and social difficulties leading to significant deficits in the child’s Health Related Quality of Life (HRQoL) [5,6].

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De novo Absence Status Epilepticus in a pediatric cohort: electroclinical pattern in a multicentre Italian patient cohort

Absence Status epilepticus (AS) is a form of Non Convulsive Status Epilepticus defined as a prolonged, generalized and non-convulsive seizure, with an altered content of consciousness. We aim to describe a group of healthy children, who present recurrent and unprovokedde novo AS as the only manifestation of their epilepsy, with an excellent response to antiepileptic drugs.

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Mindfulness-Based Cognitive Therapy for Sexuality (MBCT-S) improves sexual functioning and intimacy among older women with epilepsy: A multicenter randomized controlled trial

Women with epilepsy (WWE) as compared with the general female population have higher estimates of sexual dysfunction (75.3% vs. 12.0%) [1–2]. Different reasons for sexual dysfunction among WWE have been proposed, including decreased libido, problems with arousal and infrequent orgasms, earlier onset of menopause, adverse effects of certain antiepileptic drugs (AEDs), anxiety, and stigmatization [3–7]. Given that sexuality is an important component of quality of life (QoL) [8] and is viewed as a central part of an individual’s life [9], ...

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New-onset super refractory status epilepticus: a case-series

Status epilepticus (SE) represents a neurological emergency that requires urgent treatment and rapid escalation of care if symptoms do not subside within a short time from onset [1]. The progression to Refractory Status Epilepticus (RSE) is reported in 40% of SE cases (Rossetti and Lowenstein. 2011), often requiring intravenous anaesthetic treatment (IVAT) and critical care admission [2]. RSE, though, still associates with substantial morbidity and mortality [3–5].

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Mutation spectrum of the SCN1A gene in a Hungarian population with epilepsy

Epilepsy, conventionally classified as idiopathic by etiology in up to 70 % of the cases, has started to reveal its genetic roots with the advent of widely available genetic testing [1]. The majority of the genes identified as disease causing mutation encode ion channels or receptors including voltage-gated sodium, potassium, calcium and chloride channels; additionally, receptors for acetylcholine and γ-amino butyric acid (GABA) [2]. The most widely investigated association is between SCN1A mutations (OMIM 182389) with Dravet syndrome (DS) (OMIM ...

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Autism spectrum disorder in children and young people with non-epileptic seizures

Non-epileptic seizures (NES) are paroxysmal events which to an observer resemble epileptic seizures, but do not have the electrophysiological correlates of epilepsy. NES are regarded as psychogenic in origin, but the diagnosis can be made without requiring identification of a psychological stressor [1]. Semiology can vary greatly between patients and a range of alternative names are used for the disorder [2].

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Influence of new versus traditional antiepileptic drugs on course and outcome of status epilepticus

Status epilepticus (SE) is a frequent neurological emergency with an incidence of 16 to 36/100,000 [1,2]. The prognosis of SE is largely determined by unmodifiable patient characteristics like age, a history of previous seizures, the patient’s premorbid functional status, the seizure semiology, EEG patterns, and particularly the etiology underlying the SE [3–8]. However, prolonged SE duration also contributes to poor prognosis, mirrored by mortality rates of 25% in refractory SE as compared to approximately 10% in non-refractory SE [9,10].

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Stereo-EEG exploration in a case of eating epilepsy with cutlery-induced seizures

A rare type of reflex seizures/epilepsy is eating seizures/epilepsy (ES/EE) with an estimated prevalence of 0.1-0.05% amongst epilepsies[1]. Eating seizures may be triggered by mastication, by the thought/sight/smell of food, by the presence of food in the mouth without chewing, by swallowing, by certain types of food, and by the texture, temperature, or food-related sounds. We present a case investigated with SEEG where eating only with cutlery use was the seizure trigger.

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BELIEFS OF PEOPLE LIVING WITH EPILEPSY IN THE ACCRA METROPOLIS, GHANA

Epilepsy is a chronic brain disorder that briefly interrupts the normal electrical activity of the brain to cause seizures [1]. Roughly 50 million people worldwide suffer from epilepsy, which accounts for 0.5% of the global burden of disease [2]. Epilepsy directly affects around 10 million people in Africa [2], with its highest prevalence in poor countries including countries in sub-Saharan Africa [3]. The incidence of epilepsy in Ghana is believed to be high as compared to the sub-Saharan African region ...

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