Human experience [1,2] and many animal models [3,4] of epilepsy follow a classic scenario of an inciting epileptogenic event followed by a latency phase before emergence of spontaneous recurrent seizures (SRS). There is evidence that tissue remodeling occurs during the latency period, which facilitates the initiation and propagation of epileptic seizures [5–7]. Biomarkers of such remodeling can be of value for diagnosis and assessment of response to therapeutic interventions. Cerebro-cerebral evoked potentials (CCEPs) recorded in the seizure network in response to low frequency stimulation (LFS) are measurable signals that may serve as such biomarkers.
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