Clinico-Psychosocial Prediction for Seizure Emergencies: A Multicenter Derivation-Validation Study

Patients with epilepsy (PWE) experience recurrent seizures that present ongoing medical challenges and disrupt daily life [1]. The unpredictable nature of seizures also imposes significant physical and emotional stress on both patients and their caregivers [2]. Effective seizure management is therefore essential, as frequent seizures are associated with reduced quality of life and increased reliance on emergency medical services [3,4]. This challenge is especially important, as recurrent seizures place a considerable burden on emergency care systems and contribute to elevated healthcare costs due to frequent hospitalizations and emergency department visits [5,6].

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