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Systemic autoimmune diseases (SAD) have gained notoriety as being a risk factor for epilepsy. Conversely, recent studies have reported that epilepsy increases the risk of systemic autoimmune diseases [1,2]. Based on the emerging data, one may speculate that there is an underlying biological mechanism, such as pro-inflammatory conditions and antibodies, which links epilepsy and SAD [2,3]. Numerous studies have focused on clarifying this association, as it could help elucidate the different roles of auto-Abs and inflammation in epileptogenesis.