Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Shayan Amiri, Arya Haj-Mirzaian, Hossein Amini-khoei, Armin Shirzadian, Maryam Rahimi-Balaei, Ali Razmi, Hugo Bergen, Mojgan Rastegar, Nastaran Kordjazy, Arvin Haj-Mirzaian, Shahram Ejtemai-Mehr, Ahmad Reza Dehpour
In this study, we tested whether acute administration of lithium mitigates the deleterious effect of adolescent social isolation stress (SIS) on seizure susceptibility. In comparison with socially conditioned (SC) mice, isolated conditioned (IC) mice exhibited an increase in seizure susceptibility to pentylenetetrazole. Acute administration of lithium (10mg/kg) reversed the proconvulsant effect of SIS in IC mice, but this effect was not observed in SC mice. Coadministration of subthreshold doses of lithium (3mg/kg) with nitric oxide synthase (NOS) inhibitors reversed the effect of SIS on seizure susceptibility and decreased hippocampal nitrite levels in IC animals. In addition, a subthreshold dose of a nitric oxide precursor reduced the protective effect of lithium on seizure susceptibility and increased nitrite levels in the hippocampus of IC mice. These results suggest that lithium exerts a protective influence against the proconvulsant effect of adolescent SIS via a nitrergic system that includes activation of neuronal NOS in the hippocampus.
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