Bilateral epilepsia partialis continua in POLG related mitochondrial disease

Epilepsia partialis continua (EPC) is a rare neurological disorder characterized by persistent focal-onset seizures with preserved awareness. These seizures can last for extended periods—ranging from hours to days or even years—and are often challenging to control [1]. EPC was first described by Aleksei Kozhevnikov in 1894, who attributed it to focal cortical encephalitis. In 1958, Rasmussen syndrome was identified as a related condition, and since then, multiple pathophysiological mechanisms have been proposed [2].

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