The base of the frontal lobe, situated in the anterior cranial fossa, is anatomically bounded medially by the gyrus rectus, laterally by the lateral orbital gyrus, frontally by the frontal pole, and dorsally by the anterior perforating substance. Due to their anatomical proximity to the orbit, these gyri are collectively called the orbitofrontal region (OFR) or the orbitofrontal cortex (OFC).[1] The OFR encompasses Brodmann areas 10, 11, 47/12, 12, 14, and part of 45. Histologically, the frontobasal cortex exhibits a highly heterogeneous structure.
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