The term developmental epileptic encephalopathy (DEEs), referring to the neurobiological process underlying epilepsy and the impact of both seizures and interictal epileptiform activity on cognitive function [1–3], was recently proposed by the International League against Epilepsy (ILAE). The term early onset DEE (EO-DEE) describes severe interictal epileptiform discharge and repeated seizures that commence within the first three years of life [4].
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