Blog

Calcineurin is a crucial protein phosphatase that mediates calcium-dependent signaling by affecting the phosphorylation of numerous proteins [1]. It is encoded by the PPP3CA gene, which is widely expressed in the brain [2]. Calcineurin comprises a catalytic domain (calcineurin A, CnA) and a regulatory domain, which in turn includes three domains: calmodulin binding (CaMB), calcineurin B binding (CnBB) and an auto-inhibitory (AI) domain [3,4]. The activation of calcineurin involves the binding of calcium to calmodulin and calcineurin B, which causes a conformational change that removes the AI domain from the catalytic site [1,5].