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Adaptor protein complex 4-associated hereditary spastic paraplegias (AP-4-HSP) are a group of complex neurodegenerative disorders with childhood onset, caused by genetic defects that affect any of the four subunits of the AP-4 obligate complex. This is one of five related hetero-tetrameric complexes, devoted to selectively drive transmembrane cargo proteins into nascent vesicles, and build machinery for vesicle budding and transport. The AP-4 complex is especially involved in the sorting of cargo proteins involved in autophagy – autophagy protein 9A (ATG9A) – and axon growth/myelination – 2-arachidonoylglycerol producing enzyme diacylglycerol lipase-beta (DAGLB).