Whether isolated epileptic seizures cause neuroaxonal damage is a subject of debate. Data from clinical observation, neuropsychological assessment and neuroimaging do not reveal whether long-term cognitive outcomes are due to seizure-related neuronal network dysfunction or structural brain damage. Microtubulus-associated protein tau (MAPT) deposition was found in brain resectates of epilepsy patients [1], and loss of brain volume in a long-term follow-up of patients with epilepsy was detected in MRI [2] suggesting neuroaxonal damage.
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