Familial mesial temporal lobe epilepsy phenotype is associated with novel LGI1 variants: a report of two families

Epilepsy is a chronic disorder of the central nervous system. With over 65 million individuals affected globally [1]. Genetically related epilepsy is one of six major causes of epilepsy. To date, more than 1,000 genes related to epilepsy have been identified, with 84 causative genes that can cause epilepsy or induce epilepsy as a primary symptom [2]. Consequently, hereditary epilepsy exacerbates the disease burden on the entire family of the affected individuals.

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