Decline in cognitive performance, motor function and sensory perception characterizes the normal brain aging, even in absence of neurodegeneration [1]. The pathophysiological bases underlying normal aging and neurodegenerative disorders remain not yet fully understood. Brain’s functional and structural plasticity, along with synaptic and neural redundancy, helps to maintain optimal brain activity in healthy elderly individuals. Processes such as impairment in neurogenesis, nerve cell senescence, alterations in neuronal integrity, functional and structural plastic remodelling, aberrant neuronal network activity and connectivity are believed to contribute to age-related brain changes [2].
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