Epileptic seizures arise from neuronal hyperexcitability, which leads to various clinical presentations depending on the topography of electrical activity [1]. The excitability of the neuronal membrane is maintained by a range of membrane proteins that control the physiological balance of ions between the intracellular space and extracellular matrix [2,3]. Voltage-gated sodium channels (VGSCs), which have been associated with multiple types of genetic epilepsy, are membrane proteins encoded by nine genes in the SCN group [4,5].
30
JUN
JUN
0