Medications are the primary treatment option for epilepsy. Sodium valproate (VPA) is a broad-spectrum anti-seizure medication(ASM) that is effective for many types of seizures. Compared with other ASM, VPA is more effective and well tolerated. However, it can still cause adverse effects in clinical practice. Tremor is considered an adverse effects of VPA, with an incidence of 5–57% [1,2]. VPA is primarily metabolizsed in the liver, with glucuronidation and β-oxidation being the major metabolic pathways, while cytochrome(CYP)-mediated oxidation is a minor metabolic pathway [3].
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