SLEEP IN JUVENILE MYOCLONIC EPILEPSY: A SYSTEMATIC REVIEW

Juvenile myoclonic epilepsy (JME) is a well-defined, adolescent onset subtype of idiopathic generalized epilepsy (IGE) and characterized by myoclonic seizures, occasional generalized tonic–clonic seizures (GTCS), and in some cases, absence seizures [1]. A distinct feature of JME is the occurrence of myoclonic jerks, often experienced upon waking in the morning [2]. A transcranial magnetic stimulation (TMS) study showed that cortical excitability increases early in the morning in patients with JME but not in subjects with focal epilepsy or controls without epilepsy, explaining the increased seizure susceptibility at this time of day [3].

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