Vigabatrin (4-aminohex-5-enoic acid, VGB) is an anti-seizure medication (ASM) commonly used in pediatric age groups for the treatment of epileptic spasms, especially in children with touberous sclerosis complex. It is a selective and irreversible inhibitor of γ-aminobutyric acid (GABA)-transaminase, an enzyme that catalyzes the inactivation of GABA, which thereby increases the level of GABA in presynaptic terminals. It also attenuates the glutamate-glutamine cycle between neurons and astroglia, reducing excitatory glutamate [1].
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