Predictors for and use of rescue medication in adults with epilepsy: A multicentre cross-sectional study from Germany

Despite adequate therapy with antiseizure medication (ASM), one-third of patients continue to have seizures, which may evolve into seizure emergencies, including seizure clusters, prolonged episodes, and status epilepticus, which represent life-threatening neurological emergencies with serious cerebral and systemic sequelae.[1,2] Rescue medications are given as needed to disrupt the progression of a seizure and forestall what would otherwise be a more prolonged or severe clinical event.[3,4]Benzodiazepines, such as diazepam, lorazepam, and midazolam, are positive allosteric modulators of GABAA receptors, whose activation leads to an increase in intracellular chloride, hyperpolarization of the cell membrane, and reduced excitation.

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