Melatonin as an add-on treatment for epilepsy: A systematic review and meta-analysis

Epilepsy is one of the most common and serious brain diseases, affecting more than 700,000 people worldwide; its incidence is bimodal and higher in infants and old adults [1]. Seizures are transient signs and/or symptoms resulting from abnormally excessive or synchronised neuronal activity in the brain [2]. Additionally, epilepsy often results in oxidative stress and brain damage [3]. Drug therapy is the most important treatment for epilepsy, and currently, anti-seizure medication (ASM) completely eliminate seizures without side effects in approximately 50% of the patients.

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