Multiple Sclerosis and Seizures: a Retrospective Observational Study in a Multiple Sclerosis Autoimmunity Center of Excellence

The prevalence of epilepsy in patients with multiple sclerosis (MS) is three to six times the prevalence in the general adult population[1]. While 1-1.5% of the general population have seizures, approximately 2-5% of people with MS have seizures. The cumulative incidence of epilepsy is also higher rising with increasing disease duration [2]. Mechanisms resulting in increased seizure risk are not fully understood. Seizures occur at different MS stages, perhaps suggesting different pathophysiology and management approach[3,4].

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