Neurological Autoantibody Prevalence in Chronic Epilepsy: Clinical and Neuropathologic Findings

Seizure is a common symptom of autoimmune encephalitis [1], and in the latest International League Against Epilepsy (ILAE) classifications guideline of epilepsy, immune etiology was listed as one of six etiologies [2]. In recent decades, the term “autoimmune epilepsy” has been increasingly used in publications; however, some are controversial, as “autoimmune epilepsy” has been applied to seizures in the acute phase of immune-mediated encephalitis [3–5]. Epilepsy is a chronic brain disorder that is different from seizures; therefore, some experts emphasize that autoimmune epilepsy should be differentiated from autoimmune seizures, and the term “acute symptomatic seizures secondary to autoimmune encephalitis” rather than “autoimmune epilepsy” is recommended to refer to seizures occurring in the setting of the active phase of immune-mediated encephalitis [5,6].

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