Exome analysis focusing on epilepsy-related genes in children and adults with sudden unexplained death

Sudden infant death syndrome (SIDS) is defined as the sudden death of an infant under one year of age, which remains unexplained after a thorough case investigation, including a complete autopsy, examination of the death scene, and review of the clinical history [1]. The ‘back to sleep’ campaign in the 1980ties, which recommended a supine sleeping position and a safe sleeping environment, contributed significantly to the decline of SIDS incidence [2]. However, the current incidence still adds up to 0.1 – 0.8 deaths per 1’000 live births and the underlying pathophysiological mechanisms of SIDS are not well understood [3].

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