In neonates, most seizures are attributable to acquired non-genetic causes, including hypoxic-ischemic encephalopathy (HIE), vascular events or infectious diseases. A considerable subgroup, however, has a genetic basis. Many epilepsy-related genes encode ion channels, and epilepsies caused by pathogenic variants in this group are often referred to as channelopathies.[1–3] Many of the channelopathies-related epilepsies are associated with defects of voltage-gated sodium, potassium or calcium channels.
25
JUN
JUN
0