Safety profile of subdural and depth electrode implantations in invasive EEG exploration of drug-resistant focal epilepsy

The prevalence of epilepsy is 0.5 – 1 %, of which two-thirds are focal epilepsies. 30 – 50 % of those patients have drug resistant seizures, and many of them can profit from non-medical therapies, particularly epilepsy surgery. Accurate and reliable localization of the epileptogenic zone (EZ) is critical for the success of epilepsy surgery [1]. In an initial noninvasive diagnostic phase, patients with drug-resistant focal epilepsy are evaluated to identify the EZ. If these methods do not provide sufficient results for surgical treatment, there is the option of performing invasive EEG (iEEG) to further narrow down the EZ [2].

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