Down syndrome (DS), caused by chromosome 21 trisomy, is the most common cause of genetic-related intellectual disability. According to recent epidemiological studies, almost 1 in 400-1500 newborns every year is diagnosed with DS. Individuals with DS may present heterogenous clinical pictures, including congenital heart diseases, hypothyroidism, diabetes, obstructive sleep apnea, hearing loss, vision problems, and developmental and behavioral disorders. Several neurological comorbidities can be associated with DS including movement disorders (e.g., myoclonus, parkinsonism, chorea), Alzheimer’s Disease (AD), cerebrovascular disease (e.g., Moya-Moya disease), and epilepsy.
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