Generalized paroxysmal fast activity as a time-locked photoparoxysmal response to specific flash frequencies in epilepsy with eyelid myoclonia

Epilepsy with eyelid myoclonia (EEM) is a generalized epilepsy syndrome characterized by photosensitivity (PS), eye closure sensitivity (ECS), and absences associated with eyelid myoclonia (EMA). EEM is a particular model to explicate epileptic neural networks over the occipital cortex, brainstem, transcortical pathways, and thalamocortical networks[1]. EEM is heterogeneous in terms of both clinical characteristics and prognosis, and its electroclinic subtypes are still being defined. Herein, we describe a generalized paroxysmal fast activity (GPFA) pattern shown to be time-locked at specific flash frequencies of intermittent photic stimulation (IPS) with eye closure (EC) in a patient with EEM.

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