Tuberous sclerosis complex (TSC) is an autosomal dominant, multi-expressed and multisystem disease with an estimated prevalence of 1:6,760-13,520 in livebirths, caused by mutations in TSC1 or TSC2 [1]. In nervous system, main abnormalities include neuronal migration, differentiation, and proliferation, contributing to typical brain tubers [1]. The typical neurological presentations include epilepsy (83.5%), intellectual disability (56.5%) and TSC-related neuropsychiatric disorders (83.2%) [2]. The most common neurologic manifestation is often drug-resistant epilepsy (DRE), causing severe morbidity and increased mortality [3].
9
ABR
ABR
0