Case definitions for onchocerciasis-associated epilepsy and nodding syndrome: A focused review

Onchocerciasis is caused by the filarial parasite Onchocerca volvulus and is transmitted through bites of infective blackflies (Simulium spp.) [1]. Infection with O. volvulus can result in skin and eye disease and is mainly controlled with community-directed treatment with ivermectin (CDTi)[1]. Recent epidemiological studies strongly suggest that onchocerciasis may directly or indirectly induce seizures and epilepsy, known as onchocerciasis-associated epilepsy (OAE) [2–6]. OAE is a form of epilepsy that appears in onchocerciasis-endemic regions with high ongoing transmission.

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