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Approximately 30% of patients with epilepsy have seizures that are refractory to anti-seizure medications (ASMs) [1–3]. The ketogenic diet (KD), a high-fat and low-carbohydrate diet, is effective for a subset of such patients [4,5]. Although the mechanism of the KD efficacy for epilepsy has not been fully elucidated, multiple mechanisms have been proposed and they may manifest anti-seizure effects in combination [6,7]. Recently, lactate dehydrogenase (LDH) inhibitors have been demonstrated to be a potential new target of ASMs based on theoretical considerations of metabolic changes induced by the KD, raising the possibility of targeting cellular metabolism in new ASM development [8].