EEG-Findings during long-term treatment with Everolimus in TSC-associated and therapy-resistant epilepsies in children

Tuberous Sclerosis Complex (TSC) is a genetic disease resulting in hyperactivity of the mammalian target of rapamycin complex 1. This leads to the formation of benign tumors in the kidney, liver, heart, retina, lungs, brain and skin; epilepsy occurs in up to 90% of TSC patients and is often refractory to treatment with antiseizure medication (ASM). EEG features in children with TSC and infantile spasms were first published in 1964 [1], a detailed description of infantile spasms was given in 1968 [2] and in more detail later on [3].