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Tuberous sclerosis complex (TSC), a rare genetic disease, involves excessive cell growth, which leads to benign tumors in several organs, including the central nervous system [1]. These cerebral hamartomas or tubers are potential substrates for neuronal hyperexcitability that induces epileptic seizures. Approximately 70-90% of patients with TSC develop epilepsy—often difficult to control with drug treatment [2–4]. Pharmaco-resistant epilepsy is twice as common as in the general epilepsy population [5].