Performance of a pediatric adaptation of the RITE2 and APE2 scores in children with autoimmune epilepsy: P-RITE2 and P-APE2 scores.

A substantial proportion of new-onset cryptogenic epilepsies have been attributed to a probable autoimmune cause, especially in adolescents and adults [1,2]. As timely immunotherapy can bring a dramatic improvement in achieving seizure control in these patients and most of them do not respond to conventional antiseizure medication (ASM) regimen, early suspicion and timely identification are important in clinical practice [3]. In the pediatric population, definite autoimmune encephalitis in which neural-specific autoantibodies are positive in high titers in plasma or cerebrospinal fluid (CSF), is numerically less conspicuous than seronegative autoimmune encephalitis, unlike adults [4].

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