Seizures are known to occur non-uniformly throughout the sleep-wake cycle. Retrospective studies showed that different seizure types occur preferentially during certain times based on sleep/wakefulness and/or clock time[1–4]. Data from patients with drug-resistant epilepsy (DRE) using seizure tracking devices found seizures to have frequent diurnal and occasional circaseptan rhythms[5]. A systematic review noted that diurnal rhythms of generalized seizures and parietal-lobe seizures appear to resemble the physiologic rhythm of cortisol[6].
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