Treatment of benzodiazepine-resistant status epilepticus: Systematic review and Network Meta-analyses

Status epilepticus (SE) is a common neurological emergency, which may be associated with significant short and long term neurological and systemic morbidity. A staged treatment protocol for management of status epilepticus is generally followed. The first line of treatment is administration of benzodiazepines; intravenous lorazepam, intravenous diazepam or intramuscular midazolam. [1, 2] However, approximately 30–40 % of all patients fail to respond to initial treatment with benzodiazepines. [3] The estimates may be higher based on recent population-based studies.

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