Blog

Sex-based research has increased significantly in the last decades, identifying remarkable differences in disease epidemiology and clinical manifestations as well as in pharmacokinetic and pharmacodynamic of drug treatments [1,2]. It is well known that there are physical differences between men and women that can alter the latter [3]. These sex-related differences have been highlighted as early as the very first months of intrauterine life. Since the first trimester of pregnancy, the composition of body mass differs between male and female fetuses, with female fetuses having a higher percentage of subcutaneous fat.