Schizencephaly is a severe malformation of the polymicrogyria spectrum that presents several anatomical particularities between patients, such as open or closed lips into the ventricles, different cleft size, bilaterality or unilaterality and location. Although correlated with epilepsy since its description in 1946, the contribution of such anatomical differences to its development and severity was unclear until the work of Kim et, al [1]. Analysing adult epileptic patients diagnosed with schizencephaly, they have elegantly shown that epilepsy severity is directly correlated to the volume of clefts and presence of open lips.
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